李卫华，女，1973年4月出生，博士、研究员，现任上海市生物医药技术研究院药物与医疗器械研究所所长、分子生殖毒理学研究组长；国家卫生健康委员会生育调节药械重点实验室副主任；复旦大学药学院药理学博士研究生导师、复旦大学公共卫生学院卫生毒理学硕士生导师、上海理工大学硕士生导师、上海大学硕士生导师。1995年获上海医科大学医学学士学位；2000年获得复旦大学医学院医学硕士学位；2010年获得复旦大学毒理学博士学位和日本名古屋大学医学院博士学位。2001~2002年赴德国柏林自由大学、2003~2004年赴日本名古屋大学医学部从事合作研究。先后获得上海市青年科技启明星、上海市浦江人才、上海市三八红旗手、上海市青年科技英才、国家科技部中青年科技创新领军人才、全国巾帼建功标兵等荣誉称号。现为中国环境诱变剂学会理事、上海市环境诱变剂学会副理事长、上海市预防医学会毒理学专委会委员、上海市毒理学会理事、上海药理学会生殖药理专业委员会委员、中国毒理学会发育毒理与发育源性疾病防控专委会委员。

主要从事新型生育调节药物与医疗器械研发、生殖药理毒理学研究、以及环境化学物对生殖发育影响的毒理学机制研究。承担了30余项国家“十一五”、“十二五”、“十三五”国家科技支撑计划、国家传染病重大专项、国家自然科学基金项目、上海市科委重点项目、上海市科委浦江人才项目、上海市科技启明星人才项目、上海市卫生和计划生育委员会项目、上海科学院项目等。发表论文100余篇，其中SCI论文50余篇；已申请获得10余项国家发明专利和10余项实用新型专利；曾获得1项省部级科技成果二等奖、1项省部级科技成果三等奖。

自主研发了一系列生殖健康新产品，包括：新药“甲磺酸酚妥拉明胶囊”获得国家药品监督管理局（NMPA）新药证书；“苯扎氯铵阴道避孕凝胶剂”获得NMPA临床批文，并完成了II期临床试验；“乙酸避孕凝胶”获得NMPA临床批文，并实施了里程碑式成果转化，目前正在开展II期临床试验；一个润滑剂产品获得上市许可；一个新型备孕凝胶产品实施了里程碑式成果转化。

联系方式：iamliweihua@foxmail.com

1. Mingjun Yang, Jingying Hu, Fang Tian, Minjie Xia, Zhijun Zhou*, Weihua Li*. Effects of Flurochloridone on the Developmental Toxicity in Zebrafish (Danio rerio) Embryo. Environmental Toxicology, 2024; 0:1–9，https://doi.org/10.1002/tox.24460,

2. Bin Pan, Yuanting Xie, Wenpu Shao, Xinyi Fang, Dongyang Han, Jingyu Li, Xiaoqing Hong, Wenyue Tu, Jiayi Shi, Mingjun Yang, Fang Tian, Minjie Xia, Jingying Hu, Jianke Ren, Haidong Kan, Yanyi Xu*, Weihua Li*. Prenatal exposure to PM2.5 disturbs the glucose metabolism of offspring fed with high-fat diet in a gender-dependent manner. Ecotoxicology and Environmental Safety. 288(2024)117404 (https://doi.org/10.1016/j.ecoenv.2024.117404)

3. Shimin Tao#, Xuan Zhang#, Long Yang, Mingjun Yang, Bin Pan, Yanyi Xu*, Weihua Li*, Jian Wang*. Nicotinamide improves the impaired extravillous trophoblast cell invasion induced by PM2.5 exposure-associated increase of TNFα secretion through the ROS/NF-κB/FLT1 pathway. Ecotoxicology and Environmental Safety 282 (2024) 116733（https://doi.org/10.1016/j.ecoenv.2024.116733）

4. Jiayi Shi, Fang Tian, Jianke Ren, Runsheng Li, Mingjun Yang*, Weihua Li*. Diesel exhaust particulate matter induces GC-1 spg cells oxidative stress by KEAP1-NRF2 pathway and inhibition of ATP5α1 S-sulfhydration. Food and Chemical Toxicology 189 (2024) 114746

5. Shimin Tao, Mingjun Yang, Bin Pan, Yuzhu Wang, Fang Tian, Dongyang Han, Wenpu Shao, Wenhui Yang, Yuanting Xie, Xinyi Fang, Minjie Xia, Jingying Hu, Haidong Kan, Weihua Li*, Yanyi Xu*. Maternal exposure to ambient PM2.5 perturbs the metabolic homeostasis of maternal serum and placenta in mice. Environmental Research 216 (2023) 114648

6. Liu, E.#, Yang, M.#, Li, Q., Cheng, Q., Wang, Y., Ye, L., Tian, F., Ding, H., Ling, Y., Xia, M., Ji, Z.-S. *, & Li, W*. Antitumor activity of a whey peptide-based enteral diet in C26 colon tumor-bearing mice. Journal of Food Science, 2023, 1–14. https://doi.org/10.1111/1750-3841.16724 

7. Mingjun Yang#, Fang Tian#, Shimin Tao, Minjie Xia, Yuzhu Wang, Jingying Hu, Bin Pan, Zhouzhou Li, Renzhen Peng, Haidong Kan, Yanyi Xu*, and Weihua Li*. Concentrated ambient fine particles exposure affects ovarian follicle development in mice. Ecotoxicology and Environmental Safety. Volume 2022, Article ID 113178. doi: 10.1016/j.ecoenv.2022.113178.

8. Shimin Tao, Xuan Zhang, Fang Tian, Bin Pan, Renzhen Peng, Yuzhu Wang, Minjie Xia, Mingjun Yang, Jingying Hu, Haidong Kan, Yanyi Xu*, Weihua Li*. Maternal exposure to ambient PM2.5 causes fetal growth restriction via the inhibition of spiral artery remodeling in mice. Ecotoxicology and Environmental Safety 237 (2022) 113512.

9. Shimin TAO#, Yanyi XU#, Minjie CHEN, Haichang ZHANG, Xingke HUANG，Zhouzhou LI, Bin PAN, Renzhen PENG,Yaning ZHU, Haidong KAN, Weihua LI*, Zhekang YING**. Exposure to different fractions of diesel exhaust PM2.5 induces different levels of pulmonary inflammation and acute phase response. Ecotoxicology and Environmental Safety. 2021, 210:111871.

10. Jingying Hu, Minjie Xia, Yuzhu Wang, Fang Tian, Bing Sun, Mingjun Yang, Wei Yang, Xuncheng Ding, Huihui Xu*, Weihua Li*. Paternal exposure to di-n-butyl-phthalate induced developmental toxicity in zebrafish (Danio rerio). Birth Defects Research. 2020;1–8. 

11. Yao Zhang, Yilan Teng, Wangwen Xiao, Beiying Xu, Ya Zhao*, Weihua Li*, Ligang Wu*. Identifying cleaved and noncleaved targets of small interfering RNAs and microRNAs in mammalian cells by SpyCLIP. Molecular therapy - Nucleic acids. DOI: 10.1016/J.OMTN.2020.10.009 

12. Minjie XIA#, Mingjun YANG#, Yuzhu WANG,Fang TIAN, Jingying HU, Wei YANG, Shimin TAO, Lu LU, Xuncheng DING, Shibo JIANG*, Weihua LI*. DL-Mandelic acid exhibits high sperm- immobilizing activity and low vaginal irritation A potential non-surfactant spermicide for contraception. Biomedicine & Pharmacotherapy.2020,126:110104.

13. Wei YANG#, Yanyi XU#, Hongjie PAN#, Fang TIAN, Yuzhu WANG,Minjie XIA, Jingying HU, Mingjun YANG, Shimin TAO, Shenfei SUN, Haidong KAN, Runsheng LI*, Zhekang YING*, Weihua LI*. Chronic exposure to Diesel Exhaust Particulate Matter impairs meiotic progression during spermatogenesis in a mouse model. Ecotoxicology and Environmental Safety. 2020, 202:110881.