杜晶，女，1973年11月出生，博士，研究员，上海市生物医药技术研究院营养与妇幼健康研究室主任，生殖健康遗传流行病学研究组组长，复旦大学博士生导师。2007年获得上海交通大学博士学位。曾在新加坡Duke-NUS医学研究生院进行博士后工作，在澳大利亚阿德莱德大学医学院生殖遗传学研究室进行访问学者研究。现任海市医师协会生殖医学医师分会、上海市抗癌协会遗传性消化道肿瘤专委会、中华医学会计划生育学分会生物信息学组、妇幼健康研究会安全避孕专委会委员及中华生殖与避孕杂志通讯编委等。

近年来致力于复杂疾病药物治疗靶点、生物标志物筛查、药物基因组学及表观遗传学等方面的科研工作。研究内容包括疾病的发病机制，遗传及表观遗传易感因素，药物靶点及分子标记物筛查等，对于生殖相关疾病分子机理研究取得了初步成果，揭示了特定功能基因多态性、DNA甲基化及非编码RNA等可能发挥的潜在作用。先后主持国家自然基金面上项目3项，曾主持和参与国家十三五科技支撑计划项目、国家973项目、国家及上海市自然科学基金等；发表论文100余篇（SCI论文80多篇），申请了四项发明专利。于2015、2021年分获妇幼健康科学技术奖自然科学奖二等奖，2021年获上海市科技系统三八红旗手，2023年获上海市巾帼建功标兵称号。

 近五年代表性学术论文(*通讯作者)：

1) Xia LJ, Huang JM, Che Q, Zhang J, Zhang ZF, Shen YP, Wang DF, Zhong YS, Liu SY,* and Du J*, A Heterozygous SPRY4 Variant Identified in Female Infertility Characterized by Early Embryonic Arrest. Human Reproduction, 2024 Nov 1;39(11):2618-2629. doi: 10.1093/humrep/deae231.

2) Shen YP, Zhu WQ, Li SC, Zhang ZF, Li M, Du J*. Integrated analyses of 5mC, 5hmC methylation and gene expression reveal pathology-associated AKT3 gene and potential biomarkers for Alzheimer’s disease, J Psychiatr Res. 2024 Oct: 178: 367-377. doi: 10.1016/j.jpsychires.2024.08.021. Epub 2024 Aug 24.

3) Shen YP, Chen FJ, Li M, Zhang ZF, Zhu WQ, Zhang M, Chen XH, XunJZ, Zhou WJ, Du J*. Associations of the MTNR1B rs10830963 Variant with Gestational Diabetes Mellitus: A Meta-Analysis. Int J Diabetes Dev Ctries. 2023 Mar.

4) Xia LJ, Shen YP, Liu SY*, Du J*. Iron overload triggering ECM-mediated Hippo/YAP pathway in follicle development: a hypothetical model endowed with therapeutic implications. Frontiers in Endocrinology, 2023 May 8;14:1174817.

5) Chen F, Li M, Fei X, Chen X, Zhang Z, Zhu W, Shen Y, Mao Y, Liu J,  Xu J*, Du J*. Predictive plasma biomarker for gestational diabetes: A case-control study in China, J Proteomics. 2022 Nov 11;271:104769. doi: 10.1016/j.jprot.2022.104769. 

6) Shen YP, Liu XL, Xu LF, Zhu WQ, Zhang ZF, Liu JW, Jiang LF, Mao YY, Xu JH, Yan XQ, Sun JJ, Liu F, Xiong XM, Chen XJ,Che Y*, Du J* . Whole-exome sequencing with the abnormal uterine bleeding in women using copper intrauterine devices. Per Med. 2022 Oct 17. doi: 10.2217/pme-2022-0060. Online ahead of print.

7) Chen FJ, Fei XP, Zhu WQ, Zhang ZF, Shen YP, Mao YY, Zhu QX, Xu JH, Zhou WJ, Li M*, Du J*. Placental DNA Methylation changes in the gestational diabetes mellitus. Epigenetics, 2022 Aug 21:1-13. doi: 10.1080/15592294.2022.2110193.

8) Zhu WQ, Gu Y, Li M, Zhang ZF, Liu JW, Shen YP, Chen FJ, Xin YW, Xia LJ, He L, Du J*. Integrated single-cell RNA sequencing and DNA methylation reveal the effects of air pollution in patients with recurrent spontaneous abortion, Clinical Epigenetics, 2022 Aug 23;14(1):105. doi: 10.1186/s13148-022-01327-2.

9) Liu JW, Zhang ZF, Zhu WQ, Shen YP, Gu Y, Zhang X, He L, Du J*. CircFBXW4 regulates human trophoblast cell proliferation and invasion via targeting miR-324-3p/TJP1 axis in recurrent spontaneous abortion. Placenta, 2022 May 28; 126:1-11 . doi: 10.1016 / j. placenta. 2022. 05. 016. Online ahead of print. 

10) Liu JW#, Gu Y#, Zhang ZF, Zhu WQ, Shen YP,Xu JH, Du J*. Expression profiles of circular RNA in human placental villus and decidua and prediction of drugs for recurrent spontaneous abortion , Am J Reprod Immunol, 2022 May 18. doi: 10.1111/aji.13578. Online ahead of print.

11) Shen YP,  Xiong Y, Zhang ZP, Zhang BH, Li AH, Zhang ZF, Ding J, Du J*, Che Y*. Whole Exome Sequencing Identifies genetic variants in Chinese Han pregnant women with Venous thromboembolism-a case control study. Thromb Res. 2022 Mar;211:49-55. doi: 10.1016/j.thromres.2022.01.015. Epub 2022 Jan 19.

12) Shen YP，Xu LF, Zhu WQ, Zhang ZF, Liu JW, Jiang LF, Liu XL, Mao YY, Xu JH, Yan XQ, Sun JJ, Liu F, Xiong XM, Chen XJ, Che Y*, Du J*. Associations of MCM8 rs3761873 and rs16991617 Variants with Abnormal Uterine Bleeding Induced by Copper Intrauterine Device. J Obstet Gynaecol Res . 2021 Dec 10. doi: 10.1111/jog.15101.

13) Song D, Hong L, Zhang ZF, Xu JH, Zhang HQ, Huang XL*, Du J*. The FSHR G-29A variant is not associated with the ovarian response to exogenous FSH stimulation.  Am J Reprod Immunol, 2021 Sep 23:e13500. doi: 10.1111/aji.13500.

14) Song XX, Wang ZL, Zhang ZF, Miao MH, Liu JW, Luan M, Du J*, Liang H*, Yuan W. Differential methylation of genes in the human placenta associated with bisphenol A exposure. Environ Res,  2021 Sep 200:111389. doi:10.1016/j.envres.2021.111389.

15) Liu JW#, Jiang LF#, Liu XL, Xu LF, Xu JH, Zhu WQ, Shen YP, Zhang ZF, Mao YY, Yan XQ, Sun JJ, Liu F, Xiong XM, Chen XJ, Che Y*, Du J*.  TMT-based quantitative proteomic profiling of the serum of patients with abnormal uterine bleeding associated with copper intrauterine device.  Int J Gynaecol Obstet. 2021 Jul;154(1):169-178.