张璇，女，1975年3月出生，研究员，遗传与发育研究组副组长，复旦大学妇产科专业硕士生导师。2003年于中国科学院动物研究所获得生理学博士学位。近年来主要从事胚胎植入和妊娠维持机制，以及复发性流产、先兆子痫以及宫内生长受限等病理妊娠发病机制的研究，致力于研究不孕不育以及病理妊娠的发病机理，并发现新的能用于预测妊娠结局的标志分子，为临床不孕不育临床诊治技术提供理论依据。近年主持包括国家自然基金面上项目2项以及国家自然基金青年项目1项；主持省部级上海市自然科学基金项目、上海市卫生和计划生育委员会科技发展基金项目等多项研究课题，并以主要参与人参与科技部国家重点研发计划以及省部级课题多项。已在生殖领域知名期刊发表SCI论文30多篇，其中以第一或者通讯作者发表SCI论文17篇，主持申请专利4项，专利授权2项。并于2024年获得上海市科技系统三八红旗手称号。获得妇幼健康研究会生殖免疫学专业委员会委员以及中国免疫学会生殖免疫分会第六届委员会委员资格。获得2019年度全国妇幼健康科学技术奖三等奖以及2022年度妇幼健康科学技术奖二等奖，参编专著《自然流产》一书。

 近五年代表性学术论文(*通讯作者)：

1. Shu-Han Yang#, Long Yang#, Yan Shi, Hao-Ran Xu, Jie Gan, Jia-Xin Shi, Yu Zhang, Shi-Long Shen, Jian Wang∗, Xuan Zhang∗. GDF15 promotes trophoblast invasion and pregnancy success via the BMPR1A/BMPR2/p-SMAD1 pathway: Implications for recurrent miscarriage. Life Sci, 2025 Mar 27:371:123586. doi: 10.1016/j.lfs.2025.123586.

2. Shu-Han Yang#, Jie Gan#, Hao-Ran Xu, Jia-Xin Shi, Jian Wang∗, Xuan Zhang∗. The BMP Signaling Pathway: Bridging Maternal-Fetal Crosstalk in Early Pregnancy Review Reprod Sci, 2025 Jan 16. doi: 10.1007/s43032-024-01777-4.

3. Jie Gan # 1, Long Yang # , Shu-Han Yang, Wen-Wen Gu, Yan Gu, Yan Shi, Jia-Xin Shi, Hao-Ran Xu, Ya-Wei Xin, Xuan Zhang∗, Jian Wang∗. FXYD1 was identified as a hub gene in recurrent miscarriage and involved in decidualization via regulating Na/K-ATPase activity. J Assist Reprod Genet. 2024 Dec 27. doi: 10.1007/s10815-024-03363-8.

4. Hao-Ran Xu 1#, Long Yang 1#, Yan Gu 2, Yan Shi 1, Shu-Han Yang 1, Jie Gan 1, Wen-Wen Gu 1∗ , Xuan Zhang 1,3∗, and Jian Wang 1. Identification of potential hub genes associated with recurrent miscarriage through combined transcriptomic and proteomic analysis. Biomolecules and Biomedicine. 2024 Oct 20. doi: 10.17305/bb.2024.11158.

5. Jia-Xin Shi #, Long Yang #, Jie Gan, Wen-Wen Gu, Yan Gu, Yan Shi, Han-Yu Jiang, Hao-Ran Xu, Shu-Han Yang, Xuan Zhang*, Jian Wang*. MiR-3074-5p Regulates Trophoblasts Function via EIF2S1/GDF15 Pathway in Recurrent Miscarriage. Reprod Sci. 2024 May;31(5):1290-1302. doi: 10.1007/s43032-023-01436-0.

6. Yan Gu#, Ning Song #, Wen-Wen Gu, Linghan Chen, Xuan Zhang*, Jian Wang. Down-regulation of miR-486-5p expression inhibits the proliferation and invasion of human extravillous trophoblasts, and decreased peripheral plasma miR-486-5p level is associated with human early pregnancy loss. Acta Biochim Biophys Sin (Shanghai), 2023 Sep 28. doi: 10.3724/abbs.2023239.

7. Xinyi Li,# Jiaxin Shi,# Weijie Zhao, Xixi Huang, Liyuan Cui1, Lu Liu, Xueling Jin, Djin Li, Xuan Zhang* and Meirong Du*. WNT16 from decidual stromal cells regulates HTR8/SVneo trophoblastic cell function via AKT/beta-catenin pathway. Reproduction. 2022 Mar 10;163(5):241-250. doi: 10.1530/REP-21-0282.

8. Nan Meng, Xinyue Wang, Yan Shi, Yanyan Mao, Qian Yang, Baohui Ju, Qianxi Zhu, Tingting Zhang, Yan Gu*, and Xuan Zhang*. miR-3074-5p/CLN8 pathway regulates decidualization in recurrent miscarriage. Reproduction. May 2021, Volume 162, Issue 1. doi.org/10.1530/REP-21-0032.

9. Gu WW, Yang L, Zhen XX, Gu Y, Xu H, Liu M, Yang Q, Zhang X*, Wang J*. Silencing SEC5 inhibits trophoblast invasion via integrin/Ca2+ signaling. Reproduction. 2020 Jan;159(1):59-71. doi: 10.1530/REP-19-0088.

10. Pi L, Zhang Z, Gu Y, Wang X, Wang J, Xu J, Liu J, Zhang X*, Du J*. DNA methylation profiling in recurrent miscarriage. PeerJ. 2020 Jan 7;8:e8196. doi: 10.7717/peerj.8196. eCollection 2020.