吴奇涵，男，1978年9月出生，博士/研究员，分子肿瘤组副组长。2006年获得复旦大学遗传学理学博士学位。

主要从事疾病遗传学及表观遗传学研究，包括了人类疾病相关新基因的发现和功能研究、表观遗传作用机制、肿瘤遗传学和表观遗传学以及生殖疾病表观遗传研究等，总共发表论文60余篇（28篇责任作者），并申请多项发明专利。近年来，致力于肿瘤表观遗传调控机制研究，包括DNMT1/UHRF1 维持性DNA甲基化酶调控和DNMT3A起始性DNA甲基化酶的调控机制等。另外，临床应用研究方面，利用高通量表观遗传分析方法筛选验证了肿瘤发生和预后相关的标志物并阐明机制；同时，发现新表观遗传治疗靶点和并开发相关治疗方法，在卵巢癌方面获得了初步结果。相关工作在生物医学科学重要SCI 期刊Cell Discovery、Journal of Hazardous Materials、Epigenetics、Current Drug Targets、Journal of Assisted Reproduction and Genetics、Frontiers in Immunology、Virology Journal、Clinical Lung Cancer、Nature Communication、Nucleic Acids Research、PLoS Pathogens、Journal of Biochemistry和Oncogenesis等知名期刊上发表。主持或参与多项国家、省部级项目，入选上海市教育部晨光人才计划，闵行区高层次人才，论文总引用次数近800次。

 近五年代表性学术论文(*通讯作者)：

1. Xia X, Cheng N, Liu Y, Yue D, Gao M, Hu C, Jiao K, Wang N, Zhu B, Chang X, Zeng M, Song J, Sun C, Yan C, Xi J, Lin J, Luo S, Wang Z, Lu J, Jones PL, Zhao C, Wu Q*, Zhu W*. 4qA D4Z4 Methylation Test as a Valuable Complement for Differential Diagnosis in Patients with a Facioscapulohumeral Muscular Dystrophy-Like Phenotype. J Mol Diagn. 2025 May;27(5):405-418.

2. Zhang, S.#, Wu, Q.#, He, W., Zhu, H., Wang, Z., Liang, H., Ni, X., Yuan, W., & Lu, D.(2025). Bisphenol A alters JUN promoter methylation, impairing steroid metabolism in placental cells and linking to sub-representative phenotypes. Gene, 941, 149210.

3. Chen, Z., Zhang, J., Wang, J., Tong, H., Pan, W., Ma, F., Wu, Q.*, & Dai, J*. (2024). N6-methyladenosine RNA modification promotes Severe Fever with Thrombocytopenia Syndrome Virus infection. PLoS Pathogens, 20(11), e1012725.

4. Xie, Z., Sun, S., Ji, H., Miao, M., He, W., Song, X., Cao, W., Wu, Q.*, Liang, H. *, & Yuan, W. (2024). Prenatal exposure to per- and polyfluoroalkyl substances and DNA methylation in the placenta: A prospective cohort study. Journal of Hazardous Materials, 463, 132845.

5. He, W., Zhu, H., Zhang, S., Shu, G., Lei, H., Wang, M., Yin, G., Ni, X.*, & Wu, Q*. (2024). Epigenetic editing of BRCA1 promoter increases cisplatin and olaparib sensitivity of ovarian cancer cells. Epigenetics, 19(1), 2357518.

6. He, W., Zhu, H., Zhang, S., Shu, G., Lei, H., Yin, G., Ni, X., Wang, M., & Wu, Q.* (2024). Promoter methylation changes in DNA damage-response genes in ovarian cancer and their correlation with prognosis. Clinical and Experimental Obstetrics & Gynecology, 51(5), 109.

7. Chen, Y., Huang, B., Liang, H., Ji, H., Wang, Z., Song, X., Zhu, H., Song, S., Yuan, W., Wu, Q. *, & Miao, M*. (2024). Gestational organophosphate esters (OPEs) exposure in association with placental DNA methylation levels of peroxisome proliferator-activated receptors (PPARs) signaling pathway-related genes. Science of the Total Environment, 947, 174569.

8. Feng, T., Tong, H., Zhang, F., Zhang, Q., Zhang, H., Zhou, X., Ruan, H., Wu, Q.*, & Dai, J*. (2024). Transcriptome study reveals tick immune genes restrict Babesia microti infection. Insect Science, 0, 1–14.

9. Haijun Zhu, Fangjia Luo, Wanhong He, Sufen Zhang, Jing Chen, Liyun Sun*,Xiaohua Ni*, Qihan Wu*. Identification of an Immune Cell Infiltration-Related Prognostic Model to Guide Immunotherapy in Endometrial Carcinoma. Clin. Exp. Obstet. Gynecol. 2023; 50(10): 204.

10. Li, J., Wang, R., Jin, J., Han, M., Chen, Z., Gao, Y., Hu, X., Zhu, H., Gao, H., Lu, K., Shao, Y., Lyu, C., Lai, W., Li, P., Hu, G., Li, J., Li, D., Wang, H., Wu, Q.*, & Wong, J*. (2020). USP7 negatively controls global DNA methylation by attenuating ubiquitinated histone-dependent DNMT1 recruitment. Cell Discovery, 6, 58.

11. He, W., Sun, Y., Zhang, S., Feng, X., Xu, M., Dai, J., Ni, X., Wang, X. *, & Wu, Q.* (2020). Profiling the DNA methylation patterns of imprinted genes in abnormal semen samples by next-generation bisulfite sequencing. Journal of Assisted Reproduction and Genetics, 37(9), 2211-2221.